The impact of Micronized Purified Flavonoid Fraction (MPPF)

The impact of Micronized Purified Flavonoid Fraction (MPPF) on the treatment of acute hemorrhoidal episodes.

The aim of this study is to evaluate the efficacy and the tolerability of Micronized Purified Flavonoid Fraction (MPFF) on symptoms and signs of acute Hemorrhoidal Disease (HD).

Patients experiencing an acute Hemorrhoidal Disease (HD) episode for less than 48h were enrolled in this randomized, double-blind, placebo-controlled study. One group received Micronized Purified Flavonoid Fraction (MPPF) (6 tablets/day x 4 days followed by 4 tablets/day x 3 days) and the other a placebo. Symptoms and signs of Hemorrhoidal Disease (HD) were assessed at day 0 (D0), day 4 (D4), and day 7 (D7) on a 4-point severity grading scale.

49 in the Micronized Purified Flavonoid Fraction (MPPF) group and 41 were included in this analysis. During the 7-day treatment, there was a significant difference in favour of Micronized Purified Flavonoid Fraction (MPPF) allowing a superior relief of pain and oedema and bleeding. The appreciation of global efficacy by patients or investigators also favoured Micronized Purified Flavonoid Fraction (MPPF) .

Micronized Purified Flavonoid Fraction (MPPF) significantly reduced the extent of pain and bleeding in the selected subjects of this study with acute hemorrhoids. The tolerability was similar in patients receiving Micronized Purified Flavonoid Fraction (MPPF) to that in patients receiving a placebo during the 7-day duration of the treatment. Micronized Purified Flavonoid Fraction (MPPF) can be considered an effective and well-tolerated agent in the treatment of acute episodes of hemorrhoids.

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