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Pathophysiological Mechanisms of Chronic Venous Disease (CVD) and Implications for Venoactive Drug Therapy

Chronic Venous Disease (CVD) is a common pathology, with significant physical and psychological impacts for patients and high economic costs for national healthcare systems.

Throughout the last decades, several risk factors for this condition have been identified, but only recently, have the roles of inflammation and endothelial dysfunction been properly assessed.

Although still incompletely understood, current knowledge of the pathophysiological mechanisms of Chronic Venous Disease (CVD) reveals several potential targets and strategies for therapeutic intervention, some of which are addressable by currently available venoactive drugs.

The roles of these drugs in the clinical improvement of venous tone and contractility, reduction of edema and inflammation, as well as in improved microcirculation and venous ulcers healing have been studied extensively, with favorable results reported in the literature. They aim to review these pathophysiological mechanisms and their implications regarding currently available venoactive drug therapies.

Source: Armando Mansilh, Int J Mol Sci, 2018 Jun 5;19⁶:1669. doi: 10.3390/ijms19061669.

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