Efficacy of Micronized Purified Flavonoid Fraction (MPFF)

Efficacy of Micronized Purified Flavonoid Fraction (MPFF) on improving quality of life in patients with Chronic Venous Disease (CVD)

The use of a venoactive drug is considered an important component of medical treatment of Chronic Venous Disease (CVD), for improving symptoms, signs of patients, recommended in guidelines on Chronic Venous Disease (CVD).

A systematic review of the databases MEDLINE, Scopus and Cochrane Central was performed, supplemented by hand searching, to identify randomized double-blind placebo-controlled trials on Micronized Purified Flavonoid Fraction (MPFF) in patients with Chronic Venous Disease (CVD).The aim was to study the effectiveness of the Micronized Purified Flavonoid Fraction (MPFF) across the spectrum of defined venous symptoms, signs, quality of life (QoL) and treatment assessment by the physician.

The main outcome measures were the evaluation of the overall effectiveness of the treatment by the physician, symptoms, leg edema and redness, skin changes, and quality of life (QoL).

On qualitative and quantitative analysis, Micronized Purified Flavonoid Fraction (MPFF) significantly improved leg symptoms, including pain, heaviness, feeling of swelling, cramps, paresthesia, burning sensation, and pruritus (itching), but also functional discomfort compared with placebo, leg redness, skin changes and quality of life (QoL).

Regarding objective assessments of leg edema, the use of Micronized Purified Flavonoid Fraction (MPFF) compared with placebo reduced ankle circumference and leg redness, improved skin changes and quality of life; and was associated with clinical improvement as assessed by the physician.

So, based on high quality evidence, Micronized Purified Flavonoid Fraction (MPFF) is highly effective in improving leg symptoms, edema and quality of life in patients with Chronic Venous Disease (CVD).

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