no desc

Role of bradykinin and nitric oxide in the cardioprotective action of angiotensin-converting enzyme inhibitors: Focus on Perindopril.

The involvement of endothelial dysfunction in all phases of the cardiovascular process makes it an important target for treatment, especially in hypertension. Antihypertensive treatments, in addition to their ability to lower blood pressure, should ideally have additional properties that specifically restore endothelial function. ON (nitric oxide) is essential for endothelial function and its production is enhanced both directly and indirectly through inhibition of angiotensin II production and reduction of bradykinin degradation by ACE inhibitors. Among the ACE inhibitors, Perindopril appears to have the greatest effects on bradykinin and has demonstrated efficacy on several markers of endothelial dysfunction, such as arterial stiffness and progression of atherosclerosis. Evidence from a series of large randomized controlled trials supports the use of Perindopril-based therapy for the treatment of hypertension to control its values and to reduce the risk of cardiovascular morbidity and mortality in a wide range of patients along the cardiovascular continuum.

Cardiol Ther August 27, 2019
SCAC 11/22 DM 389 SERVIER-For the exclusive use of the health care professional
Background Vimeo Live Event

Keep up to date with our content

Subscribe to our newsletter so that you are always up to date with the news.

You can unsubscribe at any time by clicking on the link in our emails.
SERVIER CENTRAL AMERICA AND THE CARIBBEAN, S.A.Edificio Dream Plaza, Costa Del Este, Ciudad de Panamá, Panamá+507-301-0227Todo el contenido de este sitio web, es sólo para los profesionales de la salud y un uso interno del evento.
LogoCopyright © 2022 Servier University by SERVIER CENTRO AMÉRICA Y EL CARIBE, S.A.