Evidence in clinical practice shows improvement in adherence

Evidence in clinical practice shows improvement in adherence with the fixed combination of 3 antihypertensive drugs

Suboptimal adherence contributes greatly to poor blood pressure control. However, in outpatients who are often treated with multiple medications, it remains highly prevalent, and only half of patients with hypertension persist with their treatment after 1 year.

A recent analysis of real world data conducted in Italy this year investigated adherence to antihypertensive combinations in a single pill of perindopril/indapamide/amlodipine.

We included patients taking dual combinations of antihypertensive/diuretic and amlodipine separately 12 months prior to the start date and those taking a single pill combination of PER/IND/AML for 6 months of follow-up.

Adherence was higher in the group of patients taking a fixed-dose combination of PER/IND/AML than with the antihypertensive-free combination (75.3% vs 44.3%, P value < 0.05).1

1.https://link.springer.com/article/10.1007/s12325-023-02451-y