Effects of BP control with perindopril/indapamide

Effects of BP control with perindopril/indapamide on the microcirculation in HT patients.

The microcirculation is responsible for mediating the exchange of gases, nutrients and metabolites between blood and tissues. It regulates perfusion according to metabolite requirements and determines peripheral vascular resistance, which is directly related to blood pressure.

The use of certain antihypertensive drugs such as ACE inhibitors has been shown to improve microvascular remodeling, thus providing significant clinical benefits.

The results of a comparative study between uncontrolled hypertensive patients, patients already treated and controlled with other antihypertensive agents (ACE inhibitors/diuretics) vs. patients treated and controlled with indapamide/peridopril using intravital videomicroscopy to measure capillary density as well as evaluating microvascular endothelial function by measuring perfusion increases by tonometry. This study confirms that the fixed-dose perindopril/indapamide combination significantly improves capillary density and improves endothelial dysfunction; in response to this improvement, a marked improvement in end-organ perfusion and a reduction in cardiovascular risk were observed.

References

SCAC 07/23 DM 458 SERVIER - For the esclusive use of the health care professional

1. Debbabi H et al. Am J Hypertens. 2010;23:1136-1143

BP: blood pressure, iECA: inhibidores de la enzima convertidora de angiotensina