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Adherence is a big deal

A recent study published; Sept 2022 in the American College of Cardiology found that in 1,245 nonadherent patients experienced worsening of their health status 1. The authors stated that strategies to improve medication adherence is needed to improve health status outcomes, regardless of treatment strategy 1

Several International guidelines: namely ACC/AHA and ESC /ESH recommends single-pill combinations to improve adherence and reduce therapeutic inertia 2. The ACC/AHA recommends combination therapy for most patients and specifically Afro population 2. Single Pill Combinations improves medication adherence and clinical outcome parameter in patients suffering from diseases like hypertension and/or dyslipidemia and led to a better clinical outcome compared to free-combination treatment under conditions of daily practice 3. The STYLE study confirms, 89.6% of patients had minor to good adherence with single pill combination, all with significant improvements in patients’ quality of life when using combination of bisoprolol/perindopril 4.

1. J Am Coll Cardiol 2022 Aug 23;80⁸755-765, RA Garcia, JA Spertus, MC Benton, PG Jones, DB Mark, JD Newman, S Bangalore, WE Boden, GW Stone, HR Reynolds, JS Hochman, DJ Maron
2. Harmonization of the AMERICAN Colllege of Cardilogy /American Heart Association and Europeon Society of Cradiology/European Society of Hypertension Blood Pressure/Hypertension Guidelines: Comparisons, Reflections and Recommendations. Eur Heart J 2022; Aug 11:
3. Weisser B, Predel HG, Gillessen A, Hacke C, Vor dem Esche J, Rippin G, Noetel A, Randerath O. Single Pill Regimen Leads to Better Adherence and Clinical Outcome in Daily Practice in Patients Suffering from Hypertension and/or Dyslipidemia: Results of a Meta-Analysis. High Blood Press Cardiovasc Prev. 2020 Apr;27²:157-164. doi: 10.1007/s40292-020-00370-5. Epub 2020 Mar 26. PMID: 32219670; PMCID: .PMC7160084.
4. Boytsov S, Burtsev, Y. Effectiveness and Tolerability of the Single-Pill.
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