Four Cornerstones in cardiovascular protection

The presence of high blood pressure increases the risk of all Cardiovascular endpoints. Most patients will need combination treatment to manage blood pressure, preferably with single-pill combinations.

Renin-angiotensin system inhibitors, thiazides or thiazides-like diuretics, calcium channel blockers, and beta-blockers are the main four cornerstone antihypertensive drugs used alone or in different ways combinations.​ Additionally, ACEi are preferable to ARBs, mainly in hypertensive patients with comorbidities​

ACEi: Angiotensin converting enzime inhibitors

ARBs Angiotensin receptor blockers

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